Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Combined Automated Annotation using Multiple IEA Methods

Low affinity Ca2+-binding sites of calcineurin B mediate conformational changes in calcineurin A.

Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.

Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.

Phosphorylation of calcipressin 1 increases its ability to inhibit calcineurin and decreases calcipressin half-life.

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.

AKAP79/150 anchoring of calcineurin controls neuronal L-type Ca2+ channel activity and nuclear signaling.

WITHDRAWN: USP14 stabilizes calcineurin and regulates NFAT/AP-1 dependent IL-4 transcription as a novel calcineurin-binding protein.

CIB1 is a regulator of pathological cardiac hypertrophy.

Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.

Na(+)/H(+) exchanger 1 directly binds to calcineurin A and activates downstream NFAT signaling, leading to cardiomyocyte hypertrophy.

The molecular mechanism of substrate engagement and immunosuppressant inhibition of calcineurin.

The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain.

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells.

A proteome-scale map of the human interactome network.

Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase.

Cooperative autoinhibition and multi-level activation mechanisms of calcineurin.

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

Investigating the human Calcineurin Interaction Network using the πɸLxVP SLiM.

The protein serine/threonine phosphatases PP2A, PP1 and calcineurin: A triple threat in the regulation of the neuronal cytoskeleton.

Architecture of the human interactome defines protein communities and disease networks.

A reference map of the human binary protein interactome.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice.

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor.

Multimodal cell maps as a foundation for structural and functional genomics.

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.

Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity.

Activation of BAD by calcineurin

Calcineurin binds NFATC1,2,3

Calcineurin binds and dephosphorylates NFAT

Translocation of CaN:CaM:NFAT to nucleus

Activation of Calcineurin

Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling

Translocation of NFATC1:CaN:CaM to nucleus

Deep research report on PPP3R1 (Falcon / Edison Scientific)