GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000116
Automatic Gene Ontology annotation based on Rhea mapping
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10848581
Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest.
PMID:11035004
C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB).
PMID:11279118
Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2.
PMID:11460167
TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
PMID:15229216
Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.
PMID:17255949
Mxi2 promotes stimulus-independent ERK nuclear translocation.
PMID:19141286
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.
PMID:20067578
MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2.
PMID:29021624
MKK6 controls T3-mediated browning of white adipose tissue.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:32707033
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:32911434
A functionally defined high-density NRF2 interactome reveals new conditional regulators of ARE transactivation.
PMID:35857590
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.
PMID:8621675
Characterization of the structure and function of a novel MAP kinase kinase (MKK6).
PMID:8622669
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
PMID:8663074
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
PMID:8663524
Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta).
PMID:9218798
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.
PMID:9768359
Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2.
Reactome:R-HSA-1247960
Activation of p38 MAPK
Reactome:R-HSA-168638
NOD1/2 Signaling Pathway
Reactome:R-HSA-2559583
Cellular Senescence
Reactome:R-HSA-3228469
MAP3K5 phosphorylates MKK3 and MKK6
Reactome:R-HSA-3238999
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5
Reactome:R-HSA-450296
Phosphorylated MKK3/MKK6 migrates to nucleus
Reactome:R-HSA-450302
activated TAK1 mediates p38 MAPK activation
Reactome:R-HSA-450333
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
Reactome:R-HSA-450346
activated human TAK1 phosphorylates MKK3/MKK6
Reactome:R-HSA-5211405
Anthrax lef cleaves target cell MAP2K6 (MEK6)
Reactome:R-HSA-6804758
Regulation of TP53 Activity through Acetylation
Reactome:R-HSA-727819
TAK1 phosphorylates MKK6
Reactome:R-HSA-8877691
MAP2K6 phosphorylates PIP4K2B
Reactome:R-HSA-9836322
p-PKR dimer phosphorylates MKK6
file:human/MAP2K6/MAP2K6-uniprot.txt
UniProt record for human MAP2K6
file:human/MAP2K6/MAP2K6-deep-research-falcon.md
Falcon deep research report for human MAP2K6