VPS34 (P22543, YLR240W) notes

Evidence journal (YeastPathways phosphoinositide_biosynthesis batch, 2026-10-06).

Activity

• Sole yeast PI3K; PI-specific PMID:7989323.
• PMID:8385367
• Autophosphorylation (protein kinase activity; non-core) PMID:7989323.
• YeastPathways step PI + ATP -> PI3P (EC 2.7.1.137) correct.

Complexes

• PMID:11157979.
• Atg38 in complex I PMID:24165940.
• Complex II structure PMID:26450213.

Location

• PAS, vacuolar membrane, endosomes PMID:16421251.
• Peroxisome PMID:21121900, NV junction PMID:23335340 minor.

Curation decisions

• protein binding rows (Vps15, Atg38, Gpa1) REMOVE (captured by complex terms).
• obsolete GO:0034045 -> MODIFY to GO:0000407.
• RCA cytosol -> MODIFY endosome membrane.
• Transcription elongation (PMID:23335340) kept non-core.