POX1 (FOX1, YGL205W; UniProt P13711) notes

• Acyl-CoA oxidase, EC 1.3.3.6, FAD-dependent, first (rate-setting) step of peroxisomal beta-oxidation; sole acyl-CoA oxidase gene in S. cerevisiae PMID:2189786.
• Disruption impairs growth on oleate; transcript induced >25-fold by oleate PMID:2189786.
• Reaction a 2,3-saturated acyl-CoA + O2 = (2E)-enoyl-CoA + H2O2; cofactor FAD; homooctamer [UniProt:P13711].
• Peroxisomal matrix; imported by Pex5p via an internal non-PTS1 site PMID:11967269.
• PHA synthesis (readout of beta-oxidation intermediates) requires acyl-CoA oxidase PMID:12819196.
• RPP0 interaction (PMID:37968396 AP-MS) is a high-throughput hit with an abundant ribosomal protein; no functional meaning.
• "fatty acid binding" IBA/IEA comes from the ACOX family InterPro signature; Pox1p binds acyl-CoA substrates, not free fatty acids - over-annotation.
• YeastPathways RCA cytosol is wrong (beta-oxidation is peroxisomal in yeast).