Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death.
Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death.
Caspase-4 is required for activation of inflammasomes.
Transmembrane Protein 214 (TMEM214) mediates endoplasmic reticulum stress-induced caspase 4 enzyme activation and apoptosis.
Inflammatory caspases are innate immune receptors for intracellular LPS.
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
Caspase-4 activation by a bacterial surface protein is mediated by cathepsin G in human gingival fibroblasts.
SERPINB1-mediated checkpoint of inflammatory caspase activation.
Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis.
Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.
NLRP6-caspase 4 inflammasome activation in response to cariogenic bacterial lipoteichoic acid in human dental pulp inflammation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11.
Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme.
Structural insights into cytokine cleavage by inflammatory caspase-4.
Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.
Modulation function of sphingomyelin molecular species in TLR4 signaling and cell death.
LPS-induced structural reorganization and polymerization drive noncanonical inflammasome activation.
Caspase-4 binds to LPS membranes with positive curvature for non-canonical inflammasome activation.
Human non-canonical inflammasomes activate CASP3 to limit intracellular Salmonella replication in macrophages.
The dynamic and heterogeneous structure of the non-canonical inflammasome.
A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
Identification and characterization of ICH-2, a novel member of the interleukin-1 beta-converting enzyme family of cysteine proteases.
CASP4 autocatalysis on LPS micelles
CASP4 autocatalysis on the bacterial surface
CASP4 binds exposed LPS on the bacterial surface
CASP4 forms dimers on the bacterial surface
CASP4 cleaves IL18 at D36
CASP4 inflammasome assembly
OspC3 ADP-riboxanates CASP4
CASP4 cleaves IL1B at D27
CASP4 cleaves IL1B at D116