Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Combined Automated Annotation using Multiple IEA Methods
Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein.
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CC10 dose-dependently suppresses Th2 cytokine (IL-4/IL-5/IL-13) expression and reduces GATA-3, in part by decreasing GATA-3 mRNA stability; in vivo CC10 reconstitution reduces Th2 cytokines and pulmonary eosinophilia.
"dose-dependent suppressive effect of CC10 was"
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CC10 does not suppress IFN-gamma and can induce IFN-gamma in naive CD4+ T cells, complicating the "negative regulation of IFN-gamma" annotation.
"induce IFN-gamma expression in naive CD4(+) T cells"
Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung.
Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and molecular basis for the variation in progesterone binding of CC10 from different species.
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Mouse CC10 binds progesterone substantially more weakly than rat CC10 or rabbit uteroglobin, casting doubt on the physiological importance of progesterone binding.
"casts doubt on the importance of such binding as a physiologic"
UniProt entry Q06318 (UTER_MOUSE), uteroglobin / Scgb1a1
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Uteroglobin binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls and weakly progesterone, and is a potent inhibitor of phospholipase A2; it is a secreted club cell protein induced by glucocorticoids.
"inhibitor of phospholipase A2."