Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic Gene Ontology annotation based on Rhea mapping

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

Microtubule stabilization specifies initial neuronal polarization.

Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.

Jab1 interacts with brain-specific kinase 2 (BRSK2) and promotes its degradation in the ubiquitin-proteasome pathway.

Synapses of amphids defective (SAD-A) kinase promotes glucose-stimulated insulin secretion through activation of p21-activated kinase (PAK1) in pancreatic β-Cells.

BRSK2 is regulated by ER stress in protein level and involved in ER stress-induced apoptosis.

APC/C(Cdh1) targets brain-specific kinase 2 (BRSK2) for degradation via the ubiquitin-proteasome pathway.

BRSK2 is a valosin-containing protein (VCP)-interacting protein that affects VCP functioning in endoplasmic reticulum-associated degradation.

Roles of tau protein in health and disease.

A central chaperone-like role for 14-3-3 proteins in human cells.

UniProt entry Q8IWQ3 (BRSK2_HUMAN)