Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.
The DNA sequence and analysis of human chromosome 6.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.
Self-assembling protein microarrays.
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
Crystal structure of the coiled-coil dimerization motif of geminin: structural and functional insights on DNA replication regulation.
Molecular structure of human geminin.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells.
The APC/C inhibitor, Emi1, is essential for prevention of rereplication.
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin.
A quantitative atlas of mitotic phosphorylation.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
HBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by Geminin.
A WD-repeat protein stabilizes ORC binding to chromatin.
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin.
Dynamic association of ORCA with prereplicative complex components regulates DNA replication initiation.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.
The Geminin and Idas coiled coils preferentially form a heterodimer that inhibits Geminin function in DNA replication licensing.
The histone demethylase LSD1/KDM1A promotes the DNA damage response.
A proteome-scale map of the human interactome network.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
De Novo GMNN Mutations Cause Autosomal-Dominant Primordial Dwarfism Associated with Meier-Gorlin Syndrome.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.
Architecture of the human interactome defines protein communities and disease networks.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions.
Geminin, an inhibitor of DNA replication, is degraded during mitosis.
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
Ubiquitinated geminin is degraded by the proteasome
GMNN incoming annotation contexts and PAINT ancestry evidence