Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes.
Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization.
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin.
Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo.
The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.
RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase.
A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels.
A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.
Cyclin A is required at two points in the human cell cycle.
Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes.
The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.
Cdc2-mediated Schwann cell migration during peripheral nerve regeneration.
Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
Fez1/Lzts1 absence impairs Cdk1/Cdc25C interaction during mitosis and predisposes mice to cancer development.
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation.
Cyclin B and cyclin A confer different substrate recognition properties on CDK2.
Cell death in leukemia: passenger protein regulation by topoisomerase inhibitors.
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis.
cdc2-cyclin B regulates eEF2 kinase activity in a cell cycle- and amino acid-dependent manner.
CDK1 promotes cell proliferation and survival via phosphorylation and inhibition of FOXO1 transcription factor.
Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Purification of proteins associated with specific genomic Loci.
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair.
The decision to enter mitosis: feedback and redundancy in the mitotic entry network.
Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition.
Cyclin-dependent kinase 1-mediated Bcl-xL/Bcl-2 phosphorylation acts as a functional link coupling mitotic arrest and apoptosis.
Defining the membrane proteome of NK cells.
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.
Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separase.
Analysis of proteomic changes induced upon cellular differentiation of the human intestinal cell line Caco-2.
Cdc2: a monopotent or pluripotent CDK?
Checkpoint recovery in cells: how a molecular understanding can help in the fight against cancer.
Ribosomal protein S3 is phosphorylated by Cdk1/cdc2 during G2/M phase.
Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C.
M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability.
Polo-like kinase is required for synaptonemal complex disassembly and phosphorylation in mouse spermatocytes.
Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis.
MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity.
The novel actin/focal adhesion-associated protein MISP is involved in mitotic spindle positioning in human cells.
The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylation.
The protein interaction landscape of the human CMGC kinase group.
Sulforaphane induced cell cycle arrest in the G2/M phase via the blockade of cyclin B1/CDC2 in human ovarian cancer cells.
CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.
Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes.
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.
Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression.
Ki67 antigen contributes to the timely accumulation of protein phosphatase 1γ on anaphase chromosomes.
RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.
A proteome-scale map of the human interactome network.
Cdk1 phosphorylates SPAT-1/Bora to trigger PLK-1 activation and drive mitotic entry in C. elegans embryos.
Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Comparative Proteomics Reveals Important Viral-Host Interactions in HCV-Infected Human Liver Cells.
Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation.
Phosphorylation of EB2 by Aurora B and CDK1 ensures mitotic progression and genome stability.
Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
Sulforaphane, a Dietary Isothiocyanate, Induces G₂/M Arrest in Cervical Cancer Cells through CyclinB1 Downregulation and GADD45β/CDC2 Association.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression.
Architecture of the human interactome defines protein communities and disease networks.
RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
An intrinsic S/G(2) checkpoint enforced by ATR.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Multisite phosphorylation determines the formation of Ska-Ndc80 macro-complexes that are essential for chromosome segregation during mitosis.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
Mitotic chromosome condensation requires phosphorylation of the centromeric protein KNL-2 in C. elegans.
CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
ATR promotes clearance of damaged DNA and damaged cells by rupturing micronuclei.
ASB7 is a negative regulator of H3K9me3 homeostasis.
ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation.
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
Simian virus 40 large T antigen affects the Saccharomyces cerevisiae cell cycle and interacts with p34CDC28.
The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity.
Inactivation of MAP2K1 by CDK1
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes
Formation of Cyclin B:Cdc2 complexes
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes
Translocation of Cyclin B1:phospho-Cdc2 to the cytoplasm
CAK phosphorylates CDK1 bound to CCNB1
CAK phosphorylates CDK1 bound to CCNA
Translocation of CCNA:p-T14-CDK1 to the nucleus
PKMYT1 phosphorylates CCNA:CDK1
Phosphorylation of Cyclin B1 in the CRS domain
Translocation of CRS phosphorylated Cyclin B1:Cdc2 complexes
Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases
WEE1 phosphorylates CCNA:CDK1
CDC25A dephosphorylates CCNA:CDK1
Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B
Ubiquitination of Cyclin A by APC/C:Cdc20 complex
Association of Cyclin B:Cdc2 with Cdc20:APC/C complex
Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2
Free APC/C phosphorylated by Cyclin B:Cdc2
Degradation of multiubiquitinated Cyclin B
Association of Cyclin A with the APC/C
Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex
Phosphorylation of Cdh1 by Cyclin B1:Cdc2
Degradation multiubiquitinated Cyclin A
CDK1 phosphorylates condensin II subunit NCAPD3
CDK1 phosphorylates CDCA5 (Sororin) at centromeres
CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
CDK1:CCNB phosphorylates NEK9
CDK1 phosphorylates NUP98
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Plk1-mediated phosphorylation of Nlp
CCNB1:p-T160-CDK1 phosphorylates NUMA1
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
CCNB:CDK1 phosphorylates BORA
CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1
CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
CDK1 phosphorylates MAPK6
(CDK1,CDK2):CCNA phosphorylates MDM2 at T218
SFN dimer binds CDK1 and CCNB1
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
CDK1 phosphorylates VCPIP1
CDK1 phosphorylates RUNX2
p-PKR dimer phosphorylates CDK1
Formation of CCNA1:CDK1 complex
Formation of CCNA2:CDK1 complex
CCNA:CDK1 phosphorylates BORA
CCNA:CDK1 complex translocates to the cytosol
CCNA:CDK1 phosphorylates WEE1
CCNA:CDK1 phosphorylates FZR1
CCNA:CDK1 phosphorylates TICRR
CCNA:CDK1 phosphorylates OBI1
CCNA:CDK1 phosphorylates SGO1
CCNA:CDK1 phosphorylates HJURP
CCNA:CDK1 phosphorylates MIS18BP1
CCNA:CDK1 phosphorylates CDC25B
Phosphorylation of Gorasp1, Golga2 and RAB1A by CDK1:CCNB
CDK1 phosphorylates Mastl
Deep research report on CDK1