Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Manual annotations that require more than one source of functional data to support the assignment of the associated GO term (IC)
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Hes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesoderm.
Dynamic expression and essential functions of Hes7 in somite segmentation.
-
Hes7 oscillates with a 2-h period and is essential for somite segmentation.
"Here, we found that Hes7 expression oscillates in 2-h cycles in the presomitic mesoderm (PSM)."
Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock.
Instability of Hes7 protein is crucial for the somite segmentation clock.
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity.
Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis.
-
Hes7 binds N-boxes in the Lfng and Hes7 promoters and represses them.
"Hes7, another cyclically expressed protein, can bind to the N-boxes on both Lfng and its own promoters and repress their activity."
Mutation of Hairy-and-Enhancer-of-Split-7 in humans causes spondylocostal dysostosis.
Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites.
The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program.
Expression of Hes7 in presomitic mesoderm