IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3.
Combined Automated Annotation using Multiple IEA Methods
Gene Ontology annotation through association of InterPro records with GO terms
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1.
C-type lectin receptors (CLRs)
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
Alpha-protein kinase 1 signaling pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
TAK1 is a ubiquitin-dependent kinase of MKK and IKK.
Direct activation of protein kinases by unanchored polyubiquitin chains.
MyD88 cascade initiated on plasma membrane
TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop.
Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process.
The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway.
TAK1 is an essential kinase for STING trafficking.
Activated TAK1 mediates phosphorylation of the IKK Complex
Activation of IKK complex
Activation of TAK1-TAB2 complex
Activated TAK1 phosphorylates MKK4/MKK7
activated human TAK1 phosphorylates MKK3/MKK6
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
Activation of TAK1 complex bound to activated TLR4 complex
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation.
Annotation inferences using phylogenetic trees
Molecular cloning of human TAK1 and its mutational analysis in human lung cancer.
Electronic Gene Ontology annotations created by ARBA machine learning models
The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner.
Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex.
Reciprocal cross-talk between Nod2 and TAK1 signaling pathways.
Vaccinia virus B1R kinase interacts with JIP1 and modulates c-Jun-dependent signaling.
The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway.
Protein phosphatase 6 down-regulates TAK1 kinase activation in the IL-1 signaling pathway.
An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.
TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
Retroviral oncoprotein Tax deregulates NF-kappaB by activating Tak1 and mediating the physical association of Tak1-IKK.
RBCK1 negatively regulates tumor necrosis factor- and interleukin-1-triggered NF-kappaB activation by targeting TAB2/3 for degradation.
Modulation of interleukin-1 transcriptional response by the interaction between VRK2 and the JIP1 scaffold protein.
GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth.
Helicobacter pylori CagA activates NF-kappaB by targeting TAK1 for TRAF6-mediated Lys 63 ubiquitination.
TRIM5 is an innate immune sensor for the retrovirus capsid lattice.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
Inhibition of autophagy by TAB2 and TAB3.
Cysteine methylation disrupts ubiquitin-chain sensing in NF-κB activation.
The germinal center kinase TNIK is required for canonical NF-κB and JNK signaling in B-cells by the EBV oncoprotein LMP1 and the CD40 receptor.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
IFIT5 positively regulates NF-κB signaling through synergizing the recruitment of IκB kinase (IKK) to TGF-β-activated kinase 1 (TAK1).
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Novel biochemical, structural, and systems insights into inflammatory signaling revealed by contextual interaction proteomics.
Proteomic characterization of the human sperm nucleus.
Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol.
TNF-α-induced E3 ligase, TRIM15 inhibits TNF-α-regulated NF-κB pathway by promoting turnover of K63 linked ubiquitination of TAK1.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
Phosphorylation of IKK-beta by TAK1
Activation of TAK1 complex bound to pUb-TRAF6
Activation of MAP3K7 in response to WNT
Polyubiquitinated TRAF6 binds the TAK1 complex
TAK1 is activated within the TAK1 complex
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex
K63polyUb-TAK1 autophosphorylates
K63polyUb-TRAF6 ubiquitinates TAK1
TRIKA2 binds K63polyUb-TRAF6 oligomer
USP18 deubiquitinates TAK1:TAB1
K63 polyubiquitinated RIP2 associates with the TAK1 complex
Phosphorylated TAK1 dissociates from the TLR3 receptor complex
Activated TLR4:TICAM1:K63pUb-TRAF6 recruits TAK1complex
Activated TRAF6:p-IRAK2 interacts with TAK1 complex
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3
Phosphorylated TAK1 leaves activated TLR receptor complex
ALPK1:ADP-heptose:p-T9-TIFA oligomer:K63pUb-TRAF6 oligomer recruits MAP3K7 (TAK1)
Auto phosphorylation of TAK1 within the ALPK1:ADP-heptose:p-T9-TIFA:pUb-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 :MAP3K7 complex
Activated TRAF6:p-IRAK2 interacts with TAK1 complex upon TLR7/8 or 9 stimulation
Ubiquitination of IKBKG by TRAF6
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
TRIM26 positively regulates the inflammatory immune response through K11-linked ubiquitination of TAB1.
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway.
Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction.
TRIM56 positively regulates TNFα-induced NF-κB signaling by enhancing the ubiquitination of TAK1.
TICAM1,TRAF6-dependent induction of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1.
Activation of recruited TAK1 within the activated TLR3 complex
Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3 upon TLR7/8 or 9 activation
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Wnt-ligand-dependent interaction of TAK1 (TGF-beta-activated kinase-1) with the receptor tyrosine kinase Ror2 modulates canonical Wnt-signalling.
Toll Like Receptor 3 (TLR3) Cascade
Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.
TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.
Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.
TRIF (TICAM1)-mediated TLR4 signaling
activated TAK1 mediates p38 MAPK activation
Fc epsilon receptor (FCERI) signaling
Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.
IL-17A upregulates P-glycoprotein expression in peripheral blood lymphocytes of patients with rheumatoid arthritis through TAK1.
F-box only protein 31 (FBXO31) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6).
TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains.
Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling.
SASH1 is a scaffold molecule in endothelial TLR4 signaling.
Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3.
Automatic Gene Ontology annotation based on Rhea mapping
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction.