file:interpro/panther/PTHR48013/PTHR48013-review.md

PANTHER family review PTHR48013: IBA propagation assessment for wis1

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000116

Automatic Gene Ontology annotation based on Rhea mapping

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10398679

Heat-shock-induced activation of stress MAP kinase is regulated by threonine- and tyrosine-specific phosphatases.

Osmostress and oxidative stress strongly activate the Wis1 MEK, which activates Spc1 via Thr-171/Tyr-173; heat-shock activation of Wis1 is weak and transient.

PMID:10749922

Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase.

A Mak/Mpr1-Mcs4 multistep phosphorelay transmits oxidative stress signals upstream to the Wis1-Spc1 cascade; Wis1 phosphorylates Spc1 on Thr-171 and Tyr-173.

PMID:12181336

Cytoplasmic localization of Wis1 MAPKK by nuclear export signal is important for nuclear targeting of Spc1/Sty1 MAPK in fission yeast.

Wis1 is the only MAPKK that activates Spc1; an N-terminal NES (and Crm1) keeps Wis1 cytoplasmic, which is required for stress-induced nuclear targeting of Spc1.

PMID:15292231

Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6.

A phosphorylation event by the conserved MAPK pathway (acting via Atf1/Pcr1) contributes to Swi6/HP1-dependent heterochromatin silencing at the mating-type region.

PMID:16823372

ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.

High-throughput localization assigns Wis1 to the cytosol.

PMID:1756736

The wis1 protein kinase is a dosage-dependent regulator of mitosis in Schizosaccharomyces pombe.

Wis1 is a dosage-dependent regulator of mitotic entry; overexpression advances mitosis and loss delays it, linking nutritional sensing to mitotic control.

PMID:23389634

Response regulator-mediated MAPKKK heteromer promotes stress signaling to the Spc1 MAPK in fission yeast.

Mcs4 stabilizes a Wis4-Win1 MAPKKK heteromer whose integrity promotes physical interaction with the Wis1 MAPKK and signaling to Spc1.

PMID:24255738

Phosphorelay-dependent and -independent regulation of MAPKKK by the Mcs4 response regulator in fission yeast.

The Wis1 MAPKK is part of the Mcs4-Wis4-Win1 complex and is released from it in response to both oxidative (phosphorelay-dependent) and osmotic (phosphorelay-independent) stress.

PMID:7501024

Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast.

Spc1 is activated by Wis1 kinase in response to osmotic stress and nutrient limitation and promotes onset of mitosis, linking G2/M control to the environment.

PMID:7657164

Pyp1 and Pyp2 PTPases dephosphorylate an osmosensing MAP kinase controlling cell size at division in fission yeast.

sty2 is allelic to wis1; delta wis1 cells cannot grow at high osmolarity, and Sty1 acts downstream of the Wis1 MAPKK.

PMID:7859738

Counteractive roles of protein phosphatase 2C (PP2C) and a MAP kinase kinase homolog in the osmoregulation of fission yeast.

Wis1 is a MEK homolog most closely related to S. cerevisiae Pbs2; wis1 mutations cause hypersensitivity to high osmolarity, and PP2C enzymes negatively regulate the Wis1 osmosignal.

PMID:8649397

Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe.

Spc1 is activated by Wis1 MAPK kinase and inhibited by Pyp1; Spc1 responds to osmotic, oxidative and heat stress and induces stress-response genes.

PMID:8824588

The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.

The Sty1/Wis1 pathway activates Atf1-dependent transcription of stress genes; Atf1-driven Pyp2 induction provides negative feedback on the pathway.

PMID:9321395

Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast.

Wis4 phosphorylates Wis1 in vitro and activates it in vivo; the Wis1-Spc1 pathway is required for survival under heat, osmotic, oxidative and nutritional stress.

PMID:9585506

Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast.

Wis1 is detected completely in the cytoplasm; stress-induced nuclear translocation of Spc1 coincides with its dissociation from Wis1.

PMID:9693384

The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity.

Win1 is a MAPKKK that phosphorylates and activates Wis1 and is the major transducer of osmostress signaling, acting in parallel with Wis4.

PMID:9718372

Evidence for a novel MAPKKK-independent pathway controlling the stress activated Sty1/Spc1 MAP kinase in fission yeast.

Sty1 is activated by the single MAPKK Wis1; the conserved Wis1 sites Ser-469 and Thr-473 are normally essential for Sty1 activation.