Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
A map of the interactome network of the metazoan C. elegans.
C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation.
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sta-1 is a negative regulator of dauer formation acting with DAF-1/DAF-8, and needs its tyrosine.
"sta-1 deficiency was complemented by reconstitution with wild-type protein, but not with a tyrosine mutant"
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STA-1 functions independently of DAF-7, DAF-4 and DAF-14 but requires DAF-1 and DAF-8.
"STA-1 functioned in the absence of DAF-7, DAF-4, and DAF-14, but it required DAF-1 and DAF-8"
C. elegans STAT: evolution of a regulatory switch.
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STA-1 binds a conserved STAT cis element and lacks the N-terminal oligomerization domain.
"STA-1 lacks the conserved amino-terminal oligomerization domain found in vertebrate and other invertebrate STAT proteins"
An Alternative STAT Signaling Pathway Acts in Viral Immunity in Caenorhabditis elegans.
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C. elegans lacks JAK; STA-1 acts in a JAK-independent antiviral pathway.
"There is no conserved homolog of the JAK kinases in C. elegans"
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STA-1 is mainly a transcriptional repressor of antiviral genes.
"These data suggest that STA-1 largely acts as a transcriptional repressor of an antiviral gene expression program."
Viral infection drives cell-intrinsic re-localization of the C. elegans immune-repressive STAT transcription factor STA-1.
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STA-1 leaves infected-cell nuclei and forms DRH-1-associated cytoplasmic puncta.
"During viral infection, STA-1 forms cytoplasmic puncta that interact with the RNA viral sensor DRH-1"
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Repressive function needs DNA-binding, nuclear localization and phosphorylation residues.
"STA-1 overexpression causes increased susceptibility to viral infection, in a manner dependent on conserved residues important for DNA binding, nuclear localization and phosphorylation"
Comparative evolutionary genomics of the STAT family of transcription factors.
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STA-1 is the C. elegans STAT ortholog.
"Previously we characterized the C. elegans STAT ortholog, sta-1."
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STA-1 has SH2, DNA-binding and STAT coiled-coil domains.
"A similar search with STA-1 produced three domains, SH2 (E-value 7.2e-31), DNA binding (E-value 1.9e-60) and STAT coiled-coil domain (E-value 8.8e-38)"
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The nematode STAT lacks the N-terminal domain found in other animal STATs, which probably reflects the ancestral domain structure.
"Prior to nematode divergence, the ancestral STAT likely had the same domain structure as the nematode STAT, lacking the N-terminal domain, which is conserved among all other known animal STATs."
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STA-1 binds a STAT consensus DNA motif in EMSA.
"although many other STAT proteins, including STA-1, score positive in this assay"
Evolution of the JAK-STAT pathway.
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C. elegans STATs share the core slime-mold-like STAT architecture (coiled-coil, DNA-binding, SH2).
"Extant members of the cnidara, the sea anemone (Nematostella vectensis) and nematode (Caenorhabditis elegans), both contain at least one STAT with architectures similar to that seen in slime mold"
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The canonical JAK-STAT pathway was assembled before protostomes diverged, so its absence in nematodes is a secondary, lineage-specific loss.
"These came together to form the canonical JAK-STAT signaling pathway prior to the divergence of protostomia"
OpenScientist deep research report for sta-1 (C. elegans)
UniProt entry for C. elegans sta-1 (Q9NAD6)
WormBase gene description for sta-1 (worm)