SPE4 (YLR146C, Q12455) notes

• Spermine synthase, EC 2.5.1.22 [UniProt:Q12455 "Reaction=S-adenosyl 3-(methylsulfanyl)propylamine + spermidine ="].
• spe4 deletion: no spermine, no spermine synthase activity; spermine not required for growth PMID:9573363.
• PAINT IBA spermidine synthase activity / spermidine biosynthetic process (PTN000168362, donor SGD:S000006273 = SPE3) are paralogue over-propagations: spe3 null (SPE4 intact) has no spermidine synthase activity PMID:9073064. Both IBA rows REMOVE with propagation_review.
• Interacts with Spe3 (HT screens); protein binding removed per policy.
• PWY3O-351 inherited "L-methionine salvage" BP -> MARK_AS_OVER_ANNOTATED.