Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Combined Automated Annotation using Multiple IEA Methods
Deep research report on TEP2 in Anopheles gambiae
-
TEP2 is a thioester-containing protein in a gene cluster on chromosome 3R
"TEP2 is a distinct An. gambiae TEP gene in a multi-gene cluster on chromosome arm 3R (29A-30E). TEP2 lies very close to TEP15"
-
TEP2 has an intact thioester motif consistent with opsonin function
"TEP2 is annotated with a present thioester (TE) motif, consistent with complement-like opsonin function"
-
TEP2 is induced in immune-perturbed mosquitoes
"In A. gambiae mosGILT-null, TEP2 (AGAP008366) whole-body transcript levels increased ~9-fold versus wild type (p=0.0001)"
UniProt entry for TEP2 (Q5TQC0)
Immunity-Related Genes and Gene Families in <i>Anopheles gambiae</i>
Evolution and Function of Thioester-Containing Proteins and the Complement System in the Innate Immune Response
-
TEPs function as innate immune effectors via thioester-mediated pathogen binding
"TEPs contain a thioester (TE) motif, GCGEQ, which includes a highly unstable covalent bond between the side groups of cysteine and nearby glutamic acid ... The active TE motif has the ability to bind to nearby accessible hydroxyl and amine groups that are present on all biological surfaces"
-
Insect TEPs are functionally analogous to vertebrate complement
"Similarly in mosquitoes, TEP molecules participate in the opsonization, phagocytosis, and melanization of bacterial pathogens and Plasmodium parasites"
A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in <i>Anopheles gambiae</i>
mosGILT controls innate immunity and germ cell development in Anopheles gambiae
-
TEP2 is strongly induced in immune-perturbed mosquitoes
"TEP2 (AGAP008366, fold change 9, p-value 0.0001) expression was increased in the whole body"