KIF1A review notes

2026-09-27 initial review (claude-code)

Sources: UniProt Q12756, cached GOA publications, plus newly cached PMID:9548721, PMID:33880452 and PMID:25265257 (verified via PubMed esummary). No Falcon deep-research file was present at review time.

• Core MF: plus-end-directed microtubule motor activity (GO:0008574). Human KAND variant biophysics: PMID:33880452.
• Synaptic vesicle precursor transport: Kif1a-null mice PMID:9548721. Added NEW GO:0048490.
• Dense core vesicle transport (rat): PMID:30021165.
• Interkinetic nuclear migration: PMID:21037580; rescued by human KIF1A. Rat Kif1a (F1M4A4) carries GO:0022027 IMP from this paper; human lacked it, so added NEW (ISS). KIF1A performs the step, so the participation test is met.
• All six PMID:32814053 protein-binding rows REMOVE (HTP interactome, uninformative).
• Retrograde DCV transport (IBA/ISS) kept as non-core: KIF1A is a plus-end motor.

Deep research (Falcon) incorporated

KIF1A-deep-research-falcon.md arrived after the first pass and agrees with the review (plus-end kinesin-3; SVP and DCV cargo): [file:human/KIF1A/KIF1A-deep-research-falcon.md "These findings establish that the motor is not merely associated with SVPs but is required for their physiologically effective delivery."]. It does not mention interkinetic nuclear migration; that NEW row rests on PMID:21037580.