Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein
-
KCTD16 identified as APP interactor via yeast two-hybrid screen and confirmed in mammalian cells
"After confirming the interactions in the mammalian system, mutated PLP1, members of the FLRT protein family, and KCTD16 were shown to interact with APP"
Deep research on KCTD16 function
-
KCTD16 is a BTB/POZ-domain auxiliary protein of GABA-B receptors forming pentameric complexes with GABAB2
"Human KCTD16 is a BTB/POZ-domain auxiliary protein that constitutively associates with the GABAB2 C-terminus in a 1:5 pentameric arrangement"
-
KCTD16 modulates GABA-B receptor signaling kinetics conferring sustained non-desensitizing responses
"KCTD8 and KCTD16 generally confer primarily non-desensitizing/sustained responses"
-
KCTD16 does not function as a Cullin3 E3 ligase adaptor
"KCTD subcluster harboring GABAB-binding proteins (including KCTD16) shows no structural propensity for Cul3 binding via BTB"
Cyberian deep research on KCTD16 function