Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Mutations in VPS33B, encoding a regulator of SNARE-dependent membrane fusion, cause arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome.
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.
Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking.
Regulation of divalent metal transporter expression in human intestinal epithelial cells following exposure to non-haem iron.
The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments.
Palmitoyl protein thioesterase 1 (PPT1) deficiency causes endocytic defects connected to abnormal saposin processing.
Integral and associated lysosomal membrane proteins.
Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis.
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.
The Salmonella virulence protein SifA is a G protein antagonist.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Defining the membrane proteome of NK cells.
Cytotoxic T lymphocyte granules are secretory lysosomes, containing both perforin and granzymes.
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.
The lysosomal polypeptide transporter TAPL: more than a housekeeping factor?
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
The lysosomal polypeptide transporter TAPL is stabilized by interaction with LAMP-1 and LAMP-2.
The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.
The giant spectrin βV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route.
Surface CD107a/LAMP-1 protects natural killer cells from degranulation-associated damage.
Arf-like GTPase Arl8b regulates lytic granule polarization and natural killer cell-mediated cytotoxicity.
Virus entry. Lassa virus entry requires a trigger-induced receptor switch.
Spastic paraplegia proteins spastizin and spatacsin mediate autophagic lysosome reformation.
Molecular cloning of cDNAs encoding lamp A, a human lysosomal membrane glycoprotein with apparent Mr approximately equal to 120,000.
Derived protein sequence, oligosaccharides, and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of lysosomal membrane glycoproteins.
A reference map of the human binary protein interactome.
Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel.
ER-phagy restrains inflammatory responses through its receptor UBAC2.
Exocytosis of azurophil granule membrane proteins
Exocytosis of ficolin-rich granule membrane proteins
Clathrin and phosphatidylinositol-4,5-bisphosphate regulate autophagic lysosome reformation.
UniProt record for human LAMP1
Proteostasis Network autophagy-lysosome pathway mappings