Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
An empirical framework for binary interactome mapping.
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
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High-confidence human mitochondrial proteome.
"We classified >8,000 proteins in mitochondrial preparations of human cells and defined a mitochondrial high-confidence proteome of >1,100 proteins (MitoCoP)."
The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.
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Armcx3 regulates neuronal mitochondrial trafficking via Kinesin/Miro/Trak2.
"Furthermore, we demonstrate that Armcx3 expression levels regulate mitochondrial dynamics and trafficking in neurons, and that Alex3 interacts with the Kinesin/Miro/Trak2 complex in a Ca(2+)-dependent manner."
The armadillo repeat-containing protein, ARMCX3, physically and functionally interacts with the developmental regulatory factor Sox10.
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ARMCX3 is an integral outer-membrane protein that binds Sox10.
"Biochemical analyses indicate that ARMCX3 is an integral membrane protein of the mitochondrial outer membrane."
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ARMCX3 enhances Sox10 transactivation without intrinsic transcriptional activity.
"In addition, although ARMCX3 does not possess intrinsic transcriptional activity, it does enhance transactivation of the nicotinic acetylcholine receptor alpha3 and beta4 subunit gene promoters by Sox10."
A mammalian-specific Alex3/Gα(q) protein complex regulates mitochondrial trafficking, dendritic complexity, and neuronal survival.
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Alex3 is required for Galpha-q control of neuronal mitochondrial trafficking.
"By generating a CNS-specific Alex3 knockout mouse line, we demonstrated that Alex3 was required for the effects of Gαq on mitochondrial trafficking and dendritic growth in neurons."
The non-canonical Wnt/PKC pathway regulates mitochondrial dynamics through degradation of the arm-like domain-containing protein Alex3.
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Wnt/PKC signalling degrades Alex3.
"While the Wnt canonical pathway did not alter the pattern of mitochondrial aggregation induced by Alex3, we observed that the Wnt/PKC non-canonical pathway regulated both mitochondrial aggregation and Alex3 protein levels, thereby rendering a mitochondrial phenotype and distribution similar to control patterns."
UniProt entry Q9UH62 (ARMX3_HUMAN)
Affinage mechanistic annotation for ARMCX3 (human)