Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry P27708 (PYR1_HUMAN), Multifunctional protein CAD
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD.
Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD.
Defining the membrane proteome of NK cells.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.
Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity.
Adenovirus preterminal protein binds to the CAD enzyme at active sites of viral DNA replication on the nuclear matrix.
CAD hexamer dehydrates N-carb-L-Asp to (S)-DHO
CAD hexamer transforms CAP to N-carb-L-Asp
CAD hexamer transforms L-Gln to CAP
Quantitative phosphoproteomics reveal mTORC1 activates de novo pyrimidine synthesis.
Autophosphorylation of the mammalian multifunctional protein that initiates de novo pyrimidine biosynthesis.
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1.
CAD mutations and uridine-responsive epileptic encephalopathy.
The multienzymatic protein CAD leading the de novo biosynthesis of pyrimidines localizes exclusively in the cytoplasm and does not translocate to the nucleus.
Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy.
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Human CAD restores uridine-independent growth in CAD-knockout U2OS cells; the complementation assay discriminates functional from damaging variants.
"CAD-KO cells expressing GFP-CAD proliferated in uridine-deprived conditions"
The dihydroorotase inhibitor 5-aminoorotic acid inhibits the metabolism in the rat of the cardioprotective drug dexrazoxane and its one-ring open metabolites.
Regulatory properties and behavior of activity of carbamoyl phosphate synthetase II (glutamine-hydrolyzing) in normal and proliferating tissues.
Localization of the multifunctional protein CAD in astrocytes of rodent brain.
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The available rodent-brain abstract explicitly describes CAD-positive astrocyte-like cells and GFAP confirmation; it does not settle the separately curated fine neuronal locations.
"CAD was observed in cells resembling astrocytes"
Effect of dimethylnitrosamine upon carbamoyl phosphate and ornithine utilization in rat liver.
Lesch-Nyhan syndrome, caffeine model: increase of purine and pyrimidine enzymes in rat brain.