Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.
Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates.
The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans.
MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events.
UniProt record for C. elegans MEK-2
Three genes of the MAP kinase cascade, mek-2, mpk-1/sur-1 and let-60 ras, are required for meiotic cell cycle progression in Caenorhabditis elegans.
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mek-2 is required with mpk-1 and let-60 for exit from pachytene
"We have found that exit from pachytene is dependent on the function of three members of the MAP kinase signaling cascade. One of these genes, mek-2, is a newly identified C. elegans MEK (MAP kinase kinase)."
The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans.
The Ras-MAPK pathway is important for olfaction in Caenorhabditis elegans.
WormBase gene description for mek-2 (worm)