Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein.
Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins.
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.
Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics.
ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion.
Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport.
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes.
Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Cdc42 regulates microtubule-dependent Golgi positioning.
β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation.
Post-translational modification of the RhoGTPase activating protein 21, ARHGAP21, by SUMO2/3.
ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells.
ARHGAP21 protein, a new partner of α-tubulin involved in cell-cell adhesion formation and essential for epithelial-mesenchymal transition.
ARHGAP21 prevents abnormal insulin release through actin rearrangement in pancreatic islets from neonatal mice.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Architecture of the human interactome defines protein communities and disease networks.
Hematopoietic defects in response to reduced Arhgap21.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
Quantitative fragmentomics allow affinity mapping of interactomes.
Author Correction: Quantitative fragmentomics allow affinity mapping of interactomes.
A central chaperone-like role for 14-3-3 proteins in human cells.
ARHGAP21 enhances metastasis in hepatocellular carcinoma by inhibiting ubiquitination of filamin A.
RHOA GAPs stimulate RHOA GTPase activity
Affinage mechanistic annotation for ARHGAP21 (human)
ARHGAP21 provenance analyses - results
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GO:0005096 is already the maximal molecular-function term for GAP activity, because substrate-specific GAP terms have been merged into it.
"`GO:0005096` is already maximal"
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GO has a PDZ-domain-binding term for the ligand side of a PDZ/PBM interaction but no reciprocal term for ARHGAP21's PDZ-domain side.
"The survivor, `GO:0030165`, is defined *"Binding to a PDZ domain of a protein"* — the ligand side — and has no descendants."
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IntAct participant ranges place the holdup survey rows on ARHGAP21's PDZ domain.
"Every `holdup assay` row maps to the **PDZ domain**."
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The YWHAZ 14-3-3 interaction is genuinely replicated rather than being one screen split into several sub-method rows.
"**14-3-3 binding is genuinely replicated**"
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ARHGAP21's PAINT IBA rows include its own accession as expected evidence rather than as circularity.
"All seven IBA rows are **self-referential**"