Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Automatic assignment of GO terms using logical inference, based on on inter-ontology links.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
Transferrin receptor is necessary for development of erythrocytes and the nervous system.
Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor.
Myo6 facilitates the translocation of endocytic vesicles from cell peripheries.
Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane.
Mechanism for multiple ligand recognition by the human transferrin receptor.
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.
The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein.
Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis.
The molecular mechanism for receptor-stimulated iron release from the plasma iron transport protein transferrin.
TTP specifically regulates the internalization of the transferrin receptor.
Release of the soluble transferrin receptor is directly regulated by binding of its ligand ferritransferrin.
Sec14 homology domain targets p50RhoGAP to endosomes and provides a link between Rab and Rho GTPases.
HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron.
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.
Characterization of transferrin receptor released by K562 erythroleukemia cells.
Binding and uptake of H-ferritin are mediated by human transferrin receptor-1.
Ebola virus uses clathrin-mediated endocytosis as an entry pathway.
Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses.
Noncanonical interactions between serum transferrin and transferrin receptor evaluated with electrospray ionization mass spectrometry.
MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis.
N-glycosylation is important for the correct intracellular localization of HFE and its ability to decrease cell surface transferrin binding.
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH.
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach.
TfR1 interacts with the IKK complex and is involved in IKK-NF-κB signalling.
Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model.
The transferrin receptor-1 membrane stub undergoes intramembrane proteolysis by signal peptide peptidase-like 2b.
Rab11 endosomes contribute to mitotic spindle organization and orientation.
Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset.
A proteome-scale map of the human interactome network.
Regulation of mitochondrial morphology and function by stearoylation of TFR1.
Establishment and Dysfunction of the Blood-Brain Barrier.
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Transferrin receptor 1 is a reticulocyte-specific receptor for Plasmodium vivax.
Transferrin Receptors TfR1 and TfR2 Bind Transferrin through Differing Mechanisms.
Cryo-EM structure of an essential Plasmodium vivax invasion complex.
Blood-Brain Barrier: From Physiology to Disease and Back.
A reference map of the human binary protein interactome.
The secreted micropeptide C4orf48 enhances renal fibrosis via an RNA-binding mechanism.
Primary structure of human transferrin receptor deduced from the mRNA sequence.
A novel iron uptake mechanism mediated by GPI-anchored human p97.
Differential effects of antimycin A on endocytosis and exocytosis of transferrin also are observed for internalization and externalization of beta-adrenergic receptors.
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding.
Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor.
Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum.
AP-2 directly binds some endocytic cargo
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
holoTF:TFRC dimer translocates from plasma membrane to endosome membrane
apoTF:TFRC dimer translocates from endosome membrane to plasma membrane
Fe3+ dissociates from holoTF:TFRC dimer
apo-Transferrin dissociates from the receptor complex
TFRC dimer binds 2xholoTF
Deep research on TFRC function
-
TFRC mRNA abundance is post-transcriptionally controlled by iron status via five iron-responsive elements (IREs) in its 3' UTR bound by IRP1/IRP2.
"The 3′ untranslated region (3′ UTR) of TFRC mRNA contains five IREs, which are short conserved stem-loop structures recognized by two functionally similar iron regulatory proteins, IRP1 and IRP2"
-
A fraction of TfR1 is constitutively trafficked from recycling endosomes to lysosomes for degradation via a Rab12/Dennd3-dependent pathway, and iron excess promotes lysosomal degradation of TfR1.
"Small GTPase Rab12 and its upstream activator Dennd3 regulate the trafficking of TfR1 from recycling endosomes to lysosomes, with Rab12 activation promoting TfR1 degradation"
Falcon deep research report on TFRC
-
TfR1/CD71 is the major cell-surface receptor mediating cellular iron import, a homodimeric type II transmembrane glycoprotein that preferentially binds diferric (holo-)transferrin and internalizes the ligand-receptor complex.
"TfR1 is the major cell-surface receptor that mediates cellular iron import by binding diferric transferrin"
-
The core trafficking cycle proceeds by clathrin/AP-2-mediated endocytosis, iron release in acidic endosomes (pH <= 5.5), and recycling of the receptor to the cell surface, completing in approximately 10-20 minutes.
"internalizes via clathrin/AP-2-mediated endocytosis, releases iron in acidic endosomes, and recycles apo-transferrin/TfR1 to the surface"
-
Iron release occurs in acidic endosomes at pH <= 5.5 followed by receptor recycling.
"acidic endosomes (pH ≤ 5.5)"
-
The cytoplasmic tyrosine-based YTRF internalization motif is critical for receptor internalization, and variants affecting this region cause an internalization defect.
"the cytoplasmic YTRF motif explaining trafficking-sensitive pathogenic variants"
-
Germline TFRC variants disrupting the YTRF-region internalization machinery (p.R22W, p.Y20H) increase surface TfR1, impair iron uptake, and cause combined immunodeficiency, establishing TfR1 as a non-redundant immune-metabolic checkpoint supplying iron for lymphocyte proliferation and mitochondrial metabolism.
"Shows TfR1 is not only an iron receptor but a nonredundant immune-metabolic checkpoint"
-
The soluble transferrin receptor (sTfR) is a circulating form generated by proteolytic cleavage/shedding of membrane TfR that rises with iron deficiency and expanded erythropoiesis and serves as a clinical biomarker.
"generated by **proteolytic cleavage/shedding** of membrane TfR; it rises in **iron deficiency** and with **expanded erythropoiesis**"
-
TfR1 is a leading receptor-mediated transcytosis target for delivering biologics across the blood-brain barrier and exploits CD71 overexpression for cancer-targeted delivery.
"TfR1 is a leading target for **receptor-mediated transcytosis (RMT)** strategies to shuttle biologics across the BBB"