Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on curation of immunofluorescence data
The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.
Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system.
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Tpr2 recognizes both Hsp70 and Hsp90 through its TPR domains, and its J domain stimulates ATP hydrolysis and polypeptide binding by Hsp70.
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Tpr2 induces ATP-independent dissociation of Hsp90 (but not Hsp70) from chaperone-substrate complexes, mediating retrograde transfer of substrates from Hsp90 onto Hsp70.
Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.
Role of the cochaperone Tpr2 in Hsp90 chaperoning.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Defining the membrane proteome of NK cells.
Global landscape of HIV-human protein complexes.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
HENA, heterogeneous network-based data set for Alzheimer's disease.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
Identification and characterization of two novel tetratricopeptide repeat-containing genes.
Regulation of HSF1-mediated heat shock response
HSP70/HSP90 chaperone cycle (Reactome)
HSP70/HSP90 chaperone cycle (Reactome)
UniProt entry Q99615 (DNJC7_HUMAN), DnaJ homolog subfamily C member 7 / Tpr2