Combined Automated Annotation using Multiple IEA Methods
An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen.
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Fel d 1 is a secreted secretoglobin (not a lipocalin) and the major cat allergen; its endogenous biological function is still unknown.
"The biological function of Fel d 1 is still unknown"
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Sebaceous glands, rather than saliva, are the main production site of Fel d 1.
"It is now recognized that the sebaceous glands, and not saliva, are the main production site"
The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family.
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Fel d 1 is an all-alpha secretoglobin structurally similar to uteroglobin, with an internal asymmetric cavity that could bind an amphipathic endogenous ligand.
"Fel d 1 that could bind an endogenous ligand"
Structural characterization of the tetrameric form of the major cat allergen Fel d 1.
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The Fel d 1 (1+2) tetramer crystal structure reveals two distinct calcium-binding sites, to which chain 2 contributes coordinating residues; PLA2 modulation via calcium sequestration is speculated by analogy to uteroglobin.
"structure of tetrameric Fel d 1 reveals two different calcium-binding sites"
Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands.
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Fel d 1 binds the TLR4 agonist LPS and enhances TLR4/TLR2 signaling via a CD14/MD2-dependent lipid-transfer mechanism, independent of glycosylation.
"bind to the TLR4 agonist LPS"
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Fel d 1 enhances TLR4/TLR2 innate immune signaling in response to lipid ligands.
"enhances signaling through the innate receptors TLR4 and TLR2"
Molecular diagnosis in cat allergy.
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Fel d 1 binds fatty acids and steroids with good affinity (best ligands lauric acid and androsterone, a volatile steroid pheromone).
"binding with good affinity to some fatty acids and steroids, the best ligands being lauric acid"
Falcon deep research report for CH2 (Fel d 1 chain 2)