GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

file:genes/ECOLX/ereB/ereB-uniprot.txt

UniProt flat file for ereB (P05789)

UniProt describes EreB as an erythromycin esterase that hydrolyzes the lactone ring.

"inactivation by hydrolyzing the lactone ring of the antibiotic."

PMID:3523438

Analysis of the nucleotide sequence of the ereB gene encoding the erythromycin esterase type II.

The primary sequence paper identifies ereB as an erythromycin esterase resistance determinant.

"ereB encodes an erythromycin esterase."

PMID:30177927

Look and Outlook on Enzyme-Mediated Macrolide Resistance.

Review-level synthesis explains the macrolide esterase mechanism and family context.

"The enzyme identified by Courvalin and his team hydrolyzes this ester bond"

file:projects/ANTIMICROBIAL_RESISTANCE/aro2go.sssom.yaml

Curated ARO to GO mapping set for AMR gene families

The AMR mapping records macrolide/erythromycin esterase as a GO molecular-function gap.

"GO has no macrolide/erythromycin esterase MF term (Ere). GO term request candidate."