Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
An adenylyl cyclase that functions during late development of Dictyostelium.
The effect of divalent cations on aggregation of Dictyostelium discoideum.
Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development.
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aca- disruption mutants have little detectable adenylyl cyclase activity and fail to aggregate, showing cAMP is required for cell-cell communication.
"has little detectable adenylyl cyclase activity and fails to aggregate"
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ACA expression restores receptor- and guanine nucleotide-regulated adenylyl cyclase activity.
"ACA expression restores receptor and guanine nucleotide-regulated adenylyl cyclase activity"
Chemoattractant signaling in dictyostelium discoideum.
A rapid and efficient method to generate multiple gene disruptions in Dictyostelium discoideum using a single selectable marker and the Cre-loxP system.
Intracellular role of adenylyl cyclase in regulation of lateral pseudopod formation during Dictyostelium chemotaxis.
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aca- cells are defective in suppressing lateral pseudopods in response to spatial and temporal cAMP gradients.
"defective in suppressing lateral pseudopods in response to a spatial gradient of cAMP"
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Intracellular cAMP, and hence adenylyl cyclase, plays an intracellular role in the chemotactic response.
"adenylyl cyclase play an intracellular role in the chemotactic response"
Phosphoinositide 3-kinase activity controls the chemoattractant-mediated activation and adaptation of adenylyl cyclase.
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ACA synthesizes the chemoattractant cAMP and is essential to relay the signal to neighboring cells; PI3K controls ACA activation and adaptation.
"which synthesizes the chemoattractant cAMP, is essential to relay the signal to"
Rap1 activation in response to cAMP occurs downstream of ras activation during Dictyostelium aggregation.
Collective cell migration requires vesicular trafficking for chemoattractant delivery at the trailing edge.
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ACA is asymmetrically distributed at the back of cells via vesicular trafficking, an essential determinant of head-to-tail migration.
"the asymmetrical distribution of adenylyl cyclase (ACA) at the back of Dictyostelium discoideum cells"
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Migrating cells leave behind ACA-containing vesicles, likely secreted as multivesicular bodies.
"likely secreted as multivesicular bodies"
KeaA, a Dictyostelium Kelch-domain protein that regulates the response to stress and development.
Regulation of multiple tip formation by caffeine in cellular slime molds.
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Caffeine decreases AcaA levels, lowering cAMP synthesis and altering the cAMP gradient during multiple-tip formation.
"Caffeine decreases adenyl cyclase-A (AcaA) levels"
Robustness of self-organizing chemoattractant field arising from precise pulse induction of its breakdown enzyme: a single-cell level analysis of PDE expression in Dictyostelium.
The green tea catechin epigallocatechin gallate (EGCG) blocks cell motility, chemotaxis and development in Dictyostelium discoideum.
Response of Dictyostelium discoideum to UV-C and involvement of poly (ADP-ribose) polymerase.
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aca is among the developmentally regulated genes profiled by RT-PCR after UV-C exposure.
"yakA, car1, aca, csA, regA"
Adenylyl cyclase localization to the uropod of aggregating Dictyostelium cells requires RacC.
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ACA localization to the uropod is required for stream formation and depends on RacC-mediated vesicle trafficking.
"The localization of adenylyl cyclase A (ACA) to uropod of cells is required for the stream formation"
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ACA-YFP is mainly associated with intracellular vesicular structures that traffic toward the plasma membrane.
"ACA-YFP is mainly associated with intracellular vesicular structures"
Curcumin inhibits development and cell adhesion in Dictyostelium discoideum: Implications for YakA signaling and GST enzyme function.
Adenylate cyclase A acting on PKA mediates induction of stalk formation by cyclic diguanylate at the Dictyostelium organizer.
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DgcA-derived c-di-GMP activates tip-expressed ACA, which acts on PKA to induce stalk genes.
"the more widely expressed DgcA activates tip-expressed ACA, which then acts on PKA to induce stalk genes"
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ACA produces the cAMP pulses coordinating morphogenetic cell movement and is highly expressed at the organizing tip.
"ACA produces the cAMP pulses that coordinate Dictyostelium morphogenetic cell movement and is highly expressed at the organizing tip"
Protein kinase A regulates the Ras, Rap1 and TORC2 pathways in response to the chemoattractant cAMP in Dictyostelium.
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RasG, Rap1 and TORC2 pathways control ACA-mediated production of intracellular cAMP, upstream of PKA.
"these pathways control the ACA-mediated production of intracellular cAMP"
Adenylyl cyclase A mRNA localized at the back of cells is actively translated in live chemotaxing Dictyostelium.
The neonicotinoid insecticide imidacloprid has unexpected effects on the growth and development of soil amoebae.
Exploring the mechanisms of cadmium tolerance and bioaccumulation in a soil amoeba.
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Cadmium exposure alters expression of genes involved in metal transport, detoxification and stress response in Dictyostelium.
"key genes involved in metal transport, detoxification, and stress response"
Extracellular adenosine deamination primes tip organizer development in Dictyostelium.
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The consecutive transformation of extracellular cAMP to adenosine and adenosine to ammonia is integral to Dictyostelium development.
"the consecutive transformation of extracellular cAMP to adenosine, and adenosine to ammonia"
Regulation of Dictyostelium adenylylcyclases by morphogen-induced modulation of cytosolic pH or Ca2+ levels.
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Weak acids that lower cytosolic pH permanently inhibit both ACA and ACG, reflecting the pH dependence of the enzymes.
"weak acids inhibit both ACA and ACG permanently"
Tetrahydropterins interfere with the G protein pathway in Dictyostelium discoideum.
Identification of detergent-resistant plasma membrane microdomains in dictyostelium: enrichment of signal transduction proteins.
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ACA, a downstream effector of cAR1, is specifically localized to plasma membrane microdomains (CHIFF).
"adenylate cyclase (ACA), were specifically localized in these structures"
Evidence that the RdeA protein is a component of a multistep phosphorelay modulating rate of development in Dictyostelium.