ClpP (CG5045, Q9VKY3) notes

2026-10-09 review session (module dmel_mitochondrial_clpxp)

• Deep research: ClpP-deep-research-falcon.md (first run completed after wrapper timeout).
• Matsushima et al. 2017 (S2 cells, full text):
• PMID:28814717
• catalytic mutant: PMID:28814717
• substrate: PMID:28814717
• complex: PMID:28814717
• Pareek et al. 2018: PMID:30374414
• Per deep research (not cached): ClpP knockout is lethal; tissue loss gives cristae defects and
  photoreceptor degeneration [ClpP-deep-research-falcon.md "whole-animal ClpP knockout is lethal"].

Decisions

• Core MF: serine-type endopeptidase activity in mitochondrial endopeptidase Clp complex.
• ATP-dependent peptidase activity (IBA/IEA): KEEP_AS_NON_CORE; ATP dependence is supplied by ClpX
  (holoenzyme-level activity). ClpX core function uses contributes_to GO:0004176.
• serine hydrolase activity (HDA) and ATPase binding (IBA): KEEP_AS_NON_CORE.