GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:1647211
The 5' untranslated region of encephalomyocarditis virus contains a sequence for very efficient binding of eukaryotic initiation factor eIF-2/2B.
PMID:8430778
Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats.
PMID:8567668
Glucose stimulates the activity of the guanine nucleotide-exchange factor eIF-2B in isolated rat islets of Langerhans.
PMID:8626696
T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3.
PMID:9341116
Inactivation of eIF2B and phosphorylation of PHAS-I in heat-shocked rat hepatoma cells.
PMID:10900014
Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach.
PMID:11323413
Characterization of the mammalian initiation factor eIF2B complex as a GDP dissociation stimulator protein.
PMID:12499492
A severe variant of childhood ataxia with central hypomyelination/vanishing white matter leukoencephalopathy related to EIF21B5 mutation.
PMID:15054402
Decreased guanine nucleotide exchange factor activity in eIF2B-mutated patients.
PMID:15060152
Mutations linked to leukoencephalopathy with vanishing white matter impair the function of the eukaryotic initiation factor 2B complex in diverse ways.
PMID:15217090
The life and death of oligodendrocytes in vanishing white matter disease.
PMID:16289705
An efficient mammalian cell-free translation system supplemented with translation factors.
PMID:25858979
Stress responses. Mutations in a translation initiation factor identify the target of a memory-enhancing compound.
PMID:27023709
Expression, purification, and crystallization of Schizosaccharomyces pombe eIF2B.
PMID:29599213
Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
PMID:31048492
Structural basis for eIF2B inhibition in integrated stress response.
Reactome:R-HSA-72670
Formation of eIF2:GDP:eIF2B intermediate
Reactome:R-HSA-72722
eIF2 activation
file:human/EIF2B3/EIF2B3-evidence/RESULTS.md
EIF2B3 source and propagation evidence