Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Loss of catalytically inactive lipid phosphatase myotubularin-related protein 12 impairs myotubularin stability and promotes centronuclear myopathy in zebrafish.
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Cell and animal experiments distinguish inactive MTMR12 from its catalytically active MTM1 partner and support a protein-stability mechanism.
"MTMR12 primarily regulates the function of myotubularin protein by affecting protein levels instead of modulating the enzymatic activity"
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Partial compensation in zebrafish supports noncatalytic MTMR12 function, not intrinsic phosphoinositide phosphatase activity.
"the catalytically inactive MTMR12 only partially but significantly rescues myotubularin function"
Exact Mtmr12 product-to-reference sequence comparison
Machine-fetched exact rat MTMR12 record; signal peptide is computational
Frozen exact-input ProtNLM output and UniProt sequence for A0A8I5ZMD5