Q88CM5 is an unreviewed, homology-inferred D-3-phosphoglycerate
dehydrogenase, so the target product line is not treated as independent
confirmation of its GOA calls
[file:PSEPK/serA/serA-uniprot.txt
"RecName: Full=D-3-phosphoglycerate dehydrogenase"].
The positive inference combines the target's reaction-discriminating PGDH_3
CDD assignment
[file:PSEPK/serA/serA-uniprot.txt "cd12176; PGDH_3"] with characterized PGDH
chemistry. PGDH converts 3-phosphoglycerate to phosphohydroxypyruvate in the
phosphorylated serine pathway
PMID:22023909,
and direct kinetic work resolves hydride transfer in the reversible PGDH
reaction
PMID:14154.
Q88CM5 also contains a C-terminal ACT domain. Bacterial PGDH ACT domains can
mediate L-serine feedback
PMID:22023909,
but that response has not been demonstrated for KT2440 SerA and remains an
experimental question. Direct enzyme-class kinetics establish that
phosphoglycerate dehydrogenase can behave as a V-type allosteric enzyme
PMID:14154.