GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:20018847

A novel type of E3 ligase for the Ufm1 conjugation system.

DDRGK1 interacts with the UFM1 E3 ligase UFL1 and is ufmylated at Lys-267; it localizes to the ER.

PMID:20228063

A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.

DDRGK1 interacts with CDK5RAP3/C53 and its stability is co-regulated; it modulates NF-kappaB signaling.

PMID:23675531

DDRGK1 regulates NF-kappaB activity by modulating IkappaBalpha stability.

DDRGK1 modulates NF-kappaB activity by regulating NFKBIA/IkappaB-alpha stability.

PMID:25219498

Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.

DDRGK1 interacts with UFL1 and is required for TRIP4/ASC1 ufmylation, affecting ERalpha transactivation.

PMID:28128204

A critical role of DDRGK1 in endoplasmic reticulum homoeostasis via regulation of IRE1alpha stability.

DDRGK1 interacts with ERN1/IRE1-alpha in a UFM1-dependent manner and regulates its stability, inhibiting the IRE1 arm of the UPR.

PMID:28263186

Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia.

Loss-of-function DDRGK1 variants cause Shohat-type spondyloepimetaphyseal dysplasia; DDRGK1 stabilizes SOX9 by inhibiting its ubiquitin-mediated degradation.

PMID:30626644

Ribosomal protein RPL26 is the principal target of UFMylation.

RPL26 is the principal cellular target of UFMylation.

PMID:32160526

A genome-wide ER-phagy screen highlights key roles of mitochondrial metabolism and ER-Resident UFMylation.

DDRGK1 and ER-resident UFMylation are required for ER-phagy and IRE1 UPR regulation.

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:35156780

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

PMID:35753586

P4HB UFMylation regulates mitochondrial function and oxidative stress.

PMID:36012204

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.

PMID:36121123

A non-canonical scaffold-type E3 ligase complex mediates protein UFMylation.

DDRGK1 is a component of the UREL complex and reads ufmylated RPL26 via its UFIM motif.

PMID:36543799

The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3.

DDRGK1 UFIM reads ufmylated substrate; UREL-dependent ufmylation of CYB5R3 drives ER-phagy.

PMID:37595036

Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control.

DDRGK1 UFIM-dependent reading of ufmylated RPL26 stabilizes 60S-UREL association and supports ribosome-associated quality control.

PMID:37795761

UFMylation of HRD1 regulates endoplasmic reticulum homeostasis.

PMID:38383785

UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER.

Cryo-EM of the UREL-60S complex shows DDRGK1 tethering and UFIM reading of ufmylated RPL26 to promote 60S recycling.

PMID:38383789

The UFM1 E3 ligase recognizes and releases 60S ribosomes from ER translocons.

UREL (UFL1/DDRGK1/CDK5RAP3) ufmylates RPL26 to release/recycle 60S ribosomes from ER translocons; DDRGK1 single-pass membrane anchor and UFIM are key.

PMID:40205054

Multimodal cell maps as a foundation for structural and functional genomics.