Human structural/biochemical evidence establishes DNA cytosine methylation, oligomerization and chromatin-guided targeting. PWWP and ADD domains have distinct targeting/regulatory roles. The protein-cysteine methyltransferase annotation has a real source: slow mouse catalytic-cysteine automethylation in DNA-free assays, suppressed by natural CpG substrate. It is non-core biochemical capacity, not an established second physiological function.
The horse deletionhuman339–374overlaps the PWWP-domain end, while ADD and catalytic domains are retained in a97.3%-identical alignment. Broad nuclear localization and expression regulation are supported; normal locus targeting is not established. Horse testis data measure DNMT3A expression and immunofluorescence but do not identify the selected accession or establish every catalytic/regulatory claim.
The reproducible alignment, source paths and hashes are in the paired comparison. Current UniProt sequences have not been proven identical to the original ProtNLM input sequences. Sequence anomalies are therefore recorded as model/transfer limitations, not as proven wrong-input pipeline errors.
The horse Edison report identifies further equine expression leads but misses the testis paper retrieved independently. Do not treat its statement about absent horse localization evidence as exhaustive. Inspect the PWWP fold and transcript model; resolve specialized exposure/germline annotations from their original source experiments.
Every seeded annotation receives a current assessment. UNDECIDED marks unresolved source-specific or biological evidence; these are initial reviews rather than a claim that every original experimental assay has been independently reproduced or verified. The human Edison report is retained as a research synthesis and source-finding aid; decisive YAML excerpts cite primary publications, source records or reproducible analysis. The validator advisory to cite the deep-research file is deliberately not satisfied by citing AI prose as biological proof.