Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

A congenital mutation of the novel gene LRRC8 causes agammaglobulinemia in humans.

Defining the membrane proteome of NK cells.

SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D.

Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.

LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

Architecture of the human interactome defines protein communities and disease networks.

Structure of a volume-regulated anion channel of the LRRC8 family.

Structure of the human volume regulated anion channel.

Cryo-EM structures of the human volume-regulated anion channel LRRC8.

LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.

LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Multimodal cell maps as a foundation for structural and functional genomics.

VRAC heteromer transports I-, Cl- from cytosol to extracellular region

Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.

SWELL1 is a glucose sensor regulating β-cell excitability and systemic glycaemia.

Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.

The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling.

Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport.

A protective cGAMP-mediated anti-tumor immune response can proceed without LRRC8/VRAC channels.