Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Gene Ontology annotation based on curation of immunofluorescence data

A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins.

Ribosome. The structure of the human mitochondrial ribosome.

Structure and Function of the Mitochondrial Ribosome.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP

MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA

55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed

Hydrolysis of GTP and dissociation of 28S and 39S subunits

GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA

MRRF binds 55S ribosome:mRNA:tRNA

55S ribosome:MTRF1 hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed

Stalled 55S mitochondrial ribosome is dissociated to yield 28S subunit and 39S subunit:mRNA:peptidyl-tRNA:tRNA

MTRF1 and GTP bind 55S ribosome:MT-CO1,MT-ND6 mRNA:peptidyl-tRNA at P-site:tRNA at E-site

ICT1 hydrolyzes the peptidyl-tRNA bond of the nascent polypeptide

55S mitochondrial ribosome:non-stop mRNA binds ICT1 (MRPL58)

Mutation in mitochondrial ribosomal protein MRPS22 leads to Cornelia de Lange-like phenotype, brain abnormalities and hypertrophic cardiomyopathy.

Antenatal mitochondrial disease caused by mitochondrial ribosomal protein (MRPS22) mutation.

Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency.

UniProt entry P82650 (RT22_HUMAN)