Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Human adenylosuccinate lyase (ADSL), cloning and characterization of full-length cDNA and its isoform, gene structure and molecular basis for ADSL deficiency in six patients.
Determination, activity and biological role of adenylosuccinate lyase in blood cells.
Expression, purification, and characterization of stable, recombinant human adenylosuccinate lyase.
Biochemical and biophysical analysis of five disease-associated human adenylosuccinate lyase mutants.
CRISPR-Cas9 induced mutations along de novo purine synthesis in HeLa cells result in accumulation of individual enzyme substrates and affect purinosome formation.
SAICAR => AICAR + Fumarate
adenylosuccinate => adenosine 5'-monophosphate + fumarate
UniProtKB P30566 (PUR8_HUMAN) adenylosuccinate lyase record
Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage.
Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction.
HIF-1α in the heart: remodeling nucleotide metabolism.
Importance of purine nucleotide cycle to energy production in skeletal muscle.
Effect of diet on adenylosuccinase activity in various organs of rat and chicken.
Purification of adenylosuccinate lyase from rat skeletal muscle by a novel affinity column. Stabilization of the enzyme, and effects of anions and fluoro analogues of the substrate.
Hypoxia drives the assembly of the multienzyme purinosome complex.
ADSL-generated fumarate binds and inhibits STING to promote tumour immune evasion.
Purine nucleotide cycle in rat renal cortex and medulla under conditions that mimic normal and low oxygen supply.
A comparison of hepatic adenylosuccinate lyase from rats fed either a chow diet or a semisynthetic basal diet low in riboflavin.