Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Genomic clusters, putative pathogen recognition molecules, and antimicrobial genes are induced by infection of C. elegans with M. nematophilum.
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Microarray study identifying genes induced during bacterial infection including immune response genes
"We defined 89 genes with statistically significant expression changes of at least twofold, of which 68 were up-regulated and 21 were down-regulated"
A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors.
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Comprehensive characterization of C. elegans bHLH transcription factors
"We comprehensively identify dimerization partners, spatiotemporal expression patterns, and DNA-binding specificities for the C. elegans bHLH family of TFs"
MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability.
The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans.
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Seminal study establishing HLH-30 as TFEB ortholog and master autophagy regulator
"the predicted TFEB orthologue HLH-30 regulates autophagy in Caenorhabditis elegans"
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Essential for lifespan extension in six longevity paradigms
"hlh-30 is essential for the extended lifespan of Caenorhabditis elegans in six mechanistically distinct longevity models, and overexpression of HLH-30 extends lifespan"
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Nuclear localization enhanced in longevity mutants
"Nuclear localization of HLH-30 is increased in all six Caenorhabditis elegans models"
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
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HLH-30 is key transcription factor for innate immunity
"By using an unbiased approach in the model Caenorhabditis elegans, we discovered that HLH-30 (known as TFEB in mammals) is a key transcription factor for host defense"
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Activated rapidly after S. aureus infection and drives 80% of host response
"HLH-30 was activated shortly after Staphylococcus aureus infection, and drove the expression of close to 80% of the host response, including antimicrobial and autophagy genes that were essential for host tolerance of infection"
Mondo complexes regulate TFEB via TOR inhibition to promote longevity in response to gonadal signals.
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MML-1/MXL-2 regulate HLH-30 nuclear localization via TOR inhibition
"MML-1 regulates nuclear localization and activity of HLH-30/TFEB, a convergent regulator of autophagy, lysosome biogenesis and longevity, by downregulating TOR signalling via LARS-1/leucyl-transfer RNA synthase"
An Evolutionarily Conserved PLC-PKD-TFEB Pathway for Host Defense.
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dkf-1/PKD required for HLH-30 activation during infection
"Gene dkf-1, which encodes a homolog of protein kinase D (PKD), was required for TFEB activation in nematodes infected with Staphylococcus aureus"
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Conserved PLC-PKD-TFEB pathway in host defense
"phospholipase C (PLC) gene plc-1 was also required for TFEB activation, downstream of Galphaq homolog egl-30 and upstream of dkf-1"
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
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HLH-30 mediates autophagy response to pore-forming toxins
"bacterial membrane pore-forming toxin (PFT) induces autophagy in an HLH-30-dependent manner in Caenorhabditis elegans"
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Cell-autonomous function in intestinal epithelium
"autophagic pathways and autophagy are induced partly at the transcriptional level through HLH-30 activation and are required to protect metazoan upon PFT intoxication"
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Required for xenophagic degradation of toxins
"autophagy controls the susceptibility of animals to PFT toxicity through xenophagic degradation of PFT and repair of membrane-pore cell-autonomously"
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Contributes to membrane pore repair
"autophagy also contributes to the intrinsic membrane pore-repair to defend against Cry5B PFT intoxication"
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.
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HLH-30 required for heat shock-induced autophagy
"Autophagy is induced in multiple tissues of Caenorhabditis elegans following hormetic heat stress or HSF-1 overexpression"
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Nuclear translocation upon heat stress in multiple tissues
"Nuclear localization of HLH-30 was imaged on day 1 of adulthood in strain MAH235 (hlh-30p::hlh-30::gfp+rol-6) raised at 20 °C and then maintained under control conditions or subjected to heat shock for 1 h at 36 °C"
Eukaryotic initiation factor EIF-3.G augments mRNA translation efficiency to regulate neuronal activity.
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HLH-30 observed in motor neurons with predominantly cytoplasmic localization
"HLH-30::GFP was observed throughout the nervous system and primarily localized to cytoplasm in all genetic backgrounds tested"