Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
The diversity of the DnaJ/Hsp40 family, the crucial partners for Hsp70 chaperones.
Huntingtin interacting proteins are genetic modifiers of neurodegeneration.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
DNAJC21 Mutations Link a Cancer-Prone Bone Marrow Failure Syndrome to Corruption in 60S Ribosome Subunit Maturation.
-
DNAJC21 associates with precursor 45S rRNA and plays a highly conserved role in the maturation of the 60S ribosomal subunit; it acts with HSPA8, PA2G4 and ZNF622, and biallelic mutations cause a cancer-prone bone marrow failure syndrome.
-
Disease mutations impair DNAJC21 interactions with the cofactors PA2G4, HSPA8 and ZNF622 involved in 60S maturation; DNAJC21 deficiency causes cytoplasmic accumulation of the 60S subunit and aberrant ribosome profiles.
UniProt entry Q5F1R6 (DJC21_HUMAN), DnaJ homolog subfamily C member 21