CRD1 (YDL142C, Q07560) notes

Activity

• CMP-forming CL synthase: CDP-DAG + PG -> CL + CMP PMID:2171667
• Gene identification; null lacks CL, PG elevated PMID:9614098

Location

• Mitochondrial inner membrane PMID:9614098

Downstream phenotypes (non-core)

• Membrane potential/import defects PMID:10777514
• Vacuolar acidification defects PMID:18799619
• Ups1 IM association depends on CL PMID:26235513

Curation observations

• YeastPathways writes the CL synthase reaction as 2 PG -> CL + glycerol (bacterial PLD-type ClsA). Wrong for Crd1 (CMP-forming, EC 2.7.8.41). GO RCA term GO:0043337 is nonetheless correct.
• Cytosol RCA -> MODIFY to mitochondrial inner membrane. Lipid biosynthetic process rows -> MODIFY to cardiolipin biosynthetic process.