Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Combined Automated Annotation using Multiple IEA Methods
UniProtKB entry Q9Y673 (ALG5_HUMAN)
A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic.
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Human ALG5 cDNA was cloned and partially complemented the CPY hypoglycosylation of an S. cerevisiae alg5 deletion strain; ALG5 was not mutated in the CDGS-Ic patients (the causal gene was ALG6). The paper contains no direct localization or topology experiment for ALG5.
"Expression of the humanALG5andALG6cDNA partially complemented the respective yeast mutations, as shown by the improved glycosylation of CPY"
Defining the membrane proteome of NK cells.
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.
Monoallelic pathogenic ALG5 variants cause atypical polycystic kidney disease and interstitial fibrosis.
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Monoallelic ALG5 variants in five families cause an ADPKD-spectrum disorder with interstitial fibrosis; ALG5 haploinsufficiency alters N-glycan synthesis in renal epithelial cells and ALG5 is required for polycystin-1 maturation and membrane and ciliary localization.
"We demonstrate that ALG5 haploinsufficiency is sufficient to alter the synthesis of the N-glycan chain in renal epithelial cells."
Falcon deep research report on human ALG5
Synthesis of dolichyl-phosphate-glucose
Synthesis of dolichyl-phosphate-glucose