Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on Enzyme Commission mapping

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000041

Gene Ontology annotation based on UniPathway vocabulary mapping

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:11331580

The tripartite motif family identifies cell compartments.

TRIM5 belongs to the TRIM/RBCC family and can self-associate and localize to cytoplasmic bodies.

PMID:18248090

TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.

Screen of 55 TRIM E3 ligases for antiretroviral activity; TRIM proteins affect early and late stages of HIV/MLV/ALV replication.

PMID:20357094

p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha.

SQSTM1/p62 associates with TRIM5alpha in cytoplasmic bodies and sustains its expression.

PMID:21512573

TRIM5 is an innate immune sensor for the retrovirus capsid lattice.

TRIM5 senses the retroviral capsid lattice as a pattern-recognition receptor; capsid binding activates its RING E3 ligase to generate, with UBE2V1-UBE2N, K63-linked polyubiquitin chains that activate the TAK1/TAB2/TAB3 complex, inducing NF-kB and MAPK/AP-1 inflammatory signaling.

PMID:22078707

TRIM5alpha associates with proteasomal subunits in cells while in complex with HIV-1 virions.

TRIM5alpha interacts with the proteasome subunit PSMC2 and other proteasomal subunits.

PMID:22291694

TRIM5alpha and Species Tropism of HIV/SIV.

TRIM5alpha recognizes the multimerized capsid (viral core) via its PRYSPRY/B30.2 domain; PRYSPRY polymorphisms determine species-specific restriction.

PMID:22493164

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

PMID:22829933

TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal degradation.

PMID:23077300

TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity.

TRIM5 (with TRIM8) activates TAK1, a downstream kinase that induces NF-kB and MAPK signaling.

PMID:25127057

TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.

TRIM5alpha regulates autophagy by acting as a platform assembling/activating ULK1 and Beclin-1, and functions as a selective autophagy receptor that directly recognizes the HIV-1 capsid protein and delivers it for autophagic degradation.

PMID:25203322

PKD1 phosphorylation-dependent degradation of SNAIL by SCF-FBXO11 regulates epithelial-mesenchymal transition and metastasis.

PMID:26618866

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

PMID:35156780

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.

Reactome:R-HSA-1031716

Expression of IFNG-stimulated genes