BNA3 (YJL060W, P47039) notes

Identity

• Class-I PLP-dependent aminotransferase; probable kynurenine--oxoglutarate transaminase (KAT), EC 2.6.1.7 [UniProt:P47039].

Key correction

• Bna3 is NOT the formylkynurenine formamidase; that is Bna7/YDR428C [PMID:18205391 "We used combined crystallographic, bioinformatic and biochemical methods to demonstrate that Bna3p is not an FKF but rather is most likely the yeast kynurenine aminotransferase, which converts kynurenine to kynurenic acid."; "demonstrate that YDR428C, which we have designated BNA7, is the yeast FKF"].
• YeastPathways still assigns Bna3 to EC 3.5.1.9 (arylformamidase) in NADSYN-PWY, PWY-5651, PWY3O-4158 and TRYPTOPHAN-DEGRADATION-1; these RCA rows (arylformamidase, and NAD+ biosynthesis that follows from it) are wrong.
• KAT branch (kynurenine -> kynurenic acid) diverts kynurenine away from NAD synthesis.
• Robot Scientist Adam work assigned 2-aminoadipate:2-oxoglutarate transaminase activity [PMID:19342587, abstract only, specific gene not named in abstract].

Localization

• Dual cytosol/mitochondria by alpha-complementation PMID:17034789; mitochondrial proteomes [PMID:16823961, PMID:24769239].