Rows: GO:0005739 IEA (GO_REF:0000120; UniProt SL-0173 plus mouse Q3U7U3), IDA
(PMID:26310625, ParkinsonsUK-UCL) and IDA (PMID:23933751, UniProt). No sub-compartment rows.
Checks:
- PMID:23933751
(HEK293T and SH-SY5Y, CCCP time course). Full text cached.
- Predicted MTS: PMID:23933751;
the R2/R6 mutant does not reach the mitochondrial fraction. No cleavage, import or
protease-protection assay.
- PMID:26310625 (abstract only).
- UniProt: [file:human/FBXO7/FBXO7-uniprot.txt "Relocates from the cytosol to depolarized mitochondria (PubMed:23933751)."]; no TM. Not in MitoCarta3.0.
Outcome: all three rows stay ACCEPT (the core mitophagy function's location), reasons record
the check. Stay at root: the PINK1/Parkin role points to the cytosolic face of the outer
membrane, the aggregation paper says "into mitochondria", and no assay separates them.