Ccz1 (Drosophila melanogaster, Q9VZL5) notes

The falcon deep research run exceeded the wrapper timeout but its report arrived later (Ccz1-deep-research-falcon.md); it adds fly autophagy data: [file:DROME/Ccz1/Ccz1-deep-research-falcon.md "a Ccz1 null allele disrupted Rab7 association with Atg8a-positive autophagic structures"].

Identity

• Longin-domain subunit that heterodimerises with Mon1 to form the Rab7 GEF; in metazoa joined by Bulli/RMC1 as a third subunit.

Literature

• PMID:32499409; PMID:32499409
• PMID:37216550
• PMID:37463208
• PMID:23418349 (Dmon1 paper; Ccz1 annotations derive from it): PMID:23418349.

Curation thoughts

• GEF activity is a property of the heterodimer: contributes_to GEF activity accepted.
• Autophagy (ISS from yeast) kept non-core: Mon1-Ccz1/RMC1 is needed for autophagic function in metazoa via Rab7, but no fly data here.