Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1.
PNPase and RhlB Interact and Reduce the Cellular Availability of Oxidized RNA in Deinococcus radiodurans.
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Purified D. radiodurans RpsA (DR_1983) binds RNA oligonucleotides in vitro, with higher affinity for 8-oxoG-containing RNA, though with micromolar Kd (much weaker than PNPase or RhlB).
"RpsA and Rho showed relatively lower affinity to the 8-oxoG-modified oligoribonucleotides"
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rpsA could not be deleted in D. radiodurans, consistent with an essential role.
"deletion of these proteins could not be achieved, likely due to their critical roles for cell viability in D. radiodurans"
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RpsA co-purifies with PNPase in D. radiodurans independently of RNA.
"RpsA (the ribosomal protein S1) was also found to interact with PNPase in D. radiodurans in an RNA-independent fashion"
Extraribosomal Functions of Bacterial Ribosomal Proteins-An Update, 2023.
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bS1 recognises and binds mRNAs at the first step of translation initiation as a component of the 30S subunit; N-terminal domains anchor it to the 30S via uS2 and C-terminal domains bind RNA.
"The two N-terminal S1 domains (D1–D2) lost their RNA-binding functions during evolution and acquired an ability to form protein–protein interactions, while the C-terminal domains (D3-D6) provide the RNA-binding capacity of bS1."
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Autogenous repression of rpsA translation is conserved mainly in gamma-proteobacteria and is not transferred to D. radiodurans.
"which are highly conserved in several families of γ-proteobacteria"
Identification of ribosomal protein S1 as a poly(A) binding protein in Escherichia coli.
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Purified E. coli S1, a 30S subunit protein, binds poly(A) and poly(C) RNA.
"The binding of S1 to poly(A) occurred"
UniProt entry Q9RSY6
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Q9RSY6 is placed in PANTHER subfamily PTHR10724:SF7, the subfamily that also contains E. coli RpsA (P0AG67).
"PANTHER; PTHR10724:SF7; SMALL RIBOSOMAL SUBUNIT PROTEIN BS1C; 1."
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The protein contains five S1 motif domains spanning residues 122-539, characteristic of the multi-domain architecture of bacterial S1 proteins.
"Pfam; PF00575; S1; 5."
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The N-terminal ~100 residues are predicted to be disordered.
"REGION 1..100"