Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors based on TFClass database
Combined Automated Annotation using Multiple IEA Methods
Deep research report on SOX2 function and mechanisms
UniProt entry for human SOX2 transcription factor
Core transcriptional regulatory circuitry in human embryonic stem cells
Sox-2 is expressed by glial and progenitor cells and Pax-6 is expressed by neuroblasts in the human subventricular zone.
Stem cell markers in the human posterior limbus and corneal endothelium of unwounded and wounded corneas.
Evidence for the presence of stem cell-like progenitor cells in human adult pancreas.
Aberrant expression of SOX2 upregulates MUC5AC gastric foveolar mucin in mucinous cancers of the colorectum and related lesions.
Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities.
SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis.
SOX2 plays a critical role in the pituitary, forebrain, and eye during human embryonic development.
Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells.
Novel mutations in LHX3 are associated with hypopituitarism and sensorineural hearing loss.
The molecular mechanism governing the oncogenic potential of SOX2 in breast cancer.
Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells.
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells.
Purification of human transcription factors Nanog and Sox2, each in complex with Skp, an Escherichia coli periplasmic chaperone.
Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate.
Foxp1 coordinates cardiomyocyte proliferation through both cell-autonomous and nonautonomous mechanisms.
Pluripotency factors regulate definitive endoderm specification through eomesodermin.
The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.
Deterministic direct reprogramming of somatic cells to pluripotency.
The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma.
A proteome-scale map of the human interactome network.
The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency.
Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation.
Regulation of ADAM10 by miR-140-5p and potential relevance for Alzheimer's disease.
LSD1 demethylase and the methyl-binding protein PHF20L1 prevent SET7 methyltransferase-dependent proteolysis of the stem-cell protein SOX2.
Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
The cDNA sequence and chromosomal location of the human SOX2 gene.
Reactome pathway annotation
POU5F1 (OCT4), SOX2, NANOG bind GSC promoter
POU5F1 (OCT4), SOX2, NANOG bind EOMES promoter
POU5F1 (OCT4), SOX2, NANOG bind STAT3 promoter
POU5F1 (OCT4), SOX2, NANOG bind FGF2 promoter
POU5F1 (OCT4), SOX2, NANOG bind TDGF1 promoter
POU5F1 (OCT4), SOX2, NANOG bind FOXD3 promoter
POU5F1 (OCT4), SOX2, NANOG bind TSC22D1 promoter
POU5F1 (OCT4), SOX2, NANOG bind HHEX promoter
POU5F1 (OCT4), SOX2, NANOG bind EPHA1 promoter
POU5F1 (OCT4), SOX2, NANOG bind SALL1 promoter
POU5F1 (OCT4), SOX2, NANOG bind DKK1 promoter
POU5F1 (OCT4), SOX2, NANOG bind ZIC3 promoter
POU5F1 (OCT4), NANOG bind CDX2 promoter
POU5F1 (OCT4), SOX2, NANOG, KLF4, PBX1, SMAD2 bind NANOG promoter
POU5F1 (OCT4), SOX2, NANOG bind SOX2 promoter
Beta-catenin binds SOX proteins
Expression of STAT3-upregulated nuclear proteins
POU5F1 (OCT4), SOX2, NANOG bind DPPA4 gene
MITF-M-dependent SOX2 gene expression