Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Combined Automated Annotation using Multiple IEA Methods
Human Elongator facilitates RNA polymerase II transcription through chromatin.
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The paper supports human Elongator in RNA polymerase II transcription through chromatin, not an ADRM1/Rpn13 role.
"human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner"
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes.
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.
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ADRM1/Rpn13 is a mammalian proteasome-interacting protein that recruits UCH37 to 26S proteasomes.
"hRpn13 recruits UCH37, a deubiquitinating enzyme known to associate with 26 proteasomes"
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ADRM1/Rpn13 depletion reduces proteasome-associated UCH37 and deubiquitinating activity.
"loss of UCH37 proteins and decrease in deubiquitinating activity of 26S proteasomes"
hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.
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ADRM1/Rpn13 is a 407-residue subunit of the human 19S regulatory complex.
"we discovered a novel 46-kDa (407 residues) subunit of its 19S regulatory complex"
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ADRM1/Rpn13 binds UCH37 and enhances its isopeptidase activity.
"The C-terminal half of hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity"
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome.
Proteasome subunit Rpn13 is a novel ubiquitin receptor.
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ADRM1/Rpn13 is a proteasomal ubiquitin receptor whose Pru domain binds ubiquitin.
"Rpn13 binds ubiquitin through a conserved amino-terminal region termed the pleckstrin-like receptor for ubiquitin (Pru) domain"
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex.
Recognition and processing of ubiquitin-protein conjugates by the proteasome.
Assembly pathway of the Mammalian proteasome base subcomplex is mediated by multiple specific chaperones.
Defining the human deubiquitinating enzyme interaction landscape.
Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis.
Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.
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Human Rpn13 serves as a receptor for both ubiquitin and Uch37.
"Rpn13 is a subunit of the proteasome that serves as a receptor for both ubiquitin and Uch37"
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hRpn2/S1 binding activates hRpn13 for ubiquitin binding.
"hRpn13 binding to the proteasome scaffolding protein hRpn2/S1 abrogates its interdomain interactions, thus activating hRpn13 for ubiquitin binding"
Next-generation sequencing to generate interactome datasets.
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
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Rpn13 ubiquitination reduces the proteasome's ability to bind and degrade ubiquitin-conjugated proteins.
"Rpn13 ubiquitination strongly decreases the proteasome's ability to bind and degrade ubiquitin-conjugated proteins"
A proteome-scale map of the human interactome network.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Architecture of the human interactome defines protein communities and disease networks.
Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.
Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13.
Regulation of Proteasome Activity by (Post-)transcriptional Mechanisms.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Proteasome in action: substrate degradation by the 26S proteasome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
An abundance of free regulatory (19S) proteasome particles regulates neuronal synapses.
Multimodal cell maps as a foundation for structural and functional genomics.
Ubiquitinated IkB is degraded
Proteasome proteolyzes ub-HIF-alpha
Proteasomal clevage of exogenous antigen (26S proteasome catalyst)
Ubiquitinated DVL is degraded by the proteasome
Degradation of multiubiquitinated Cdh1
Degradation of multiubiquitinated cell cycle proteins
Degradation of multiubiquitinated Securin
SCF-mediated degradation of Emi1
Degradation multiubiquitinated Cyclin A
Degradation of ubiquitinated CD4
Proteosome-mediated degradation of APOBEC3G
Degradation of ubiquitinated p27/p21 by the 26S proteasome
APC/C:Cdh1-mediated degradation of Skp2
Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex
Degradation of ubiquitinated beta catenin by the proteasome
Proteasome mediated degradation of COP1
26S proteosome degrades ODC holoenzyme complex
Ub-RibC-AXIN is degraded by the proteasome
AUF1:mRNA complex is degraded
PRICKLE1 is degraded by the proteasome
Ubiquitinated AXIN is degraded by the proteasome
Ubiquitinated DVL1 is degraded by the proteasome
Hh C-terminal fragments are degraded by the proteasome
processing defective Hh variants are degraded by the proteasome
26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex
26S proteasome processes p-7S-p100:RELB to form p52:RELB
GLI3 is partially degraded by the proteasome to yield the GLI3 repressor
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP
GLI1 is degraded by the proteasome after ubiquitination by ITCH
GLI2,3 are degraded by the proteasome
ub-GLI is degraded by the proteasome
NF1 is degraded by the proteasome
ADRM1:26S proteaseome binds UCHL5
ADRM1 binds 26S proteasome
Protesomal degradation of K48polyUb-TRAF3
26Sproteasome degrades K48polyUb-NIK
MAPK6 is degraded by the 26S proteasome
ADRM1:26S proteaseome binds USP14
Ubiquitinated geminin is degraded by the proteasome
Ubiquitinated Orc1 is degraded by the proteasome
Ubiquitinated Cdc6 is degraded by the proteasome
Proteolytic degradation of ubiquitinated-Cdc25A
Proteasome mediated degradation of Cyclin D1
Proteasome degrades polyubiquitinated PTEN
GTSE1 facilitates proteasome-mediated degradation of TP53
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
Proteasome-mediated degradation of PolyUb-FBXL7
misfolded CFTR is degraded by the 26S proteasome
CFTR F508del is degraded by the 26S proteasome
26S proteasome degrades Ub-NFE2L2
26S proteasome degrades PolyUb-RUNX2
Polyubiquitinated RUNX3 is degraded by the proteasome
NEDD8 and UBD bind NUB1 and the 26S proteasome
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
26S proteasome degrades TP73 polyubiquitinated by ITCH
26S proteasome degrades HIFalpha
ub UBXN7 is degraded by the 26S proteasome
Ub,pS335,S338,T NFE2L2 is degraded
Proteasome-dependent degradation of ubiquitinated CDH1
Proteasomal cleavage of substrate
Formation of the 19S regulatory particle base precursor
Formation of the 19S regulatory particle precursor
Formation of the 26S proteasome
Ubiquitinated CD274 is degraded by the 26S proteasome
SPOP-mediated degradation of CD274 by 26S Proteosome
Proteasomal degradation of polyUb-p-S195-CD274
Proteolysis of K48polyUb-K,p-S-PER1,2,3
The proteasome degrades the K48-polyubiquitinated alanine-tailed nascent peptide
Proteasome mediated degradation of PAK-2p34
Gli2is degraded by the proteasome
Proteasome degrades SAX-3 ubiquitinated by EBAX-1
Proteasome degrades ubiquitinated mouse NICD4
ADRM1 manual deep research
Proteostasis PN projected annotations