Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structural basis of IAP recognition by Smac/DIABLO.
Structural basis of caspase-7 inhibition by XIAP.
Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain.
Structural basis for the inhibition of caspase-3 by XIAP.
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).
IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.
Mechanism of XIAP-mediated inhibition of caspase-9.
A novel role for XIAP in copper homeostasis through regulation of MURR1.
cIAP1 Localizes to the nuclear compartment and modulates the cell cycle.
Towards a proteome-scale map of the human protein-protein interaction network.
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
Engineered hybrid dimers: tracking the activation pathway of caspase-7.
Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation.
XIAP: cell death regulation meets copper homeostasis.
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis.
Che-1 activates XIAP expression in response to DNA damage.
IAPs: more than just inhibitors of apoptosis proteins.
Binding properties of the C-terminal domain of VIAF.
S-nitrosylation of XIAP compromises neuronal survival in Parkinson's disease.
X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization.
Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
XIAP mediates NOD signaling via interaction with RIP2.
Regulation of the copper chaperone CCS by XIAP-mediated ubiquitination.
Molecular interaction between HAX-1 and XIAP inhibits apoptosis.
To fight or die - inhibitor of apoptosis proteins at the crossroad of innate immunity and death.
ARTS and Siah collaborate in a pathway for XIAP degradation.
Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity.
Survivin monomer plays an essential role in apoptosis regulation.
TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).
ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists.
The USP19 deubiquitinase regulates the stability of c-IAP1 and c-IAP2.
cIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).
IAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradation.
RIP1 is required for IAP inhibitor-mediated sensitization of childhood acute leukemia cells to chemotherapy-induced apoptosis.
XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling.
Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death.
Molecular and biochemical characterization of a unique mutation in CCS, the human copper chaperone to superoxide dismutase.
The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex.
Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling.
Dual regulatory switch confers tighter control on HtrA2 proteolytic activity.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines.
A proteome-scale map of the human interactome network.
A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations.
Widespread macromolecular interaction perturbations in human genetic disorders.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Architecture of the human interactome defines protein communities and disease networks.
The role of the LB structural loop and its interactions with the PDZ domain of the human HtrA3 protease.
Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis.
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.
Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling.
Discerning the mechanism of action of HtrA4: a serine protease implicated in the cell death pathway.
The HtrA3 protease promotes drug-induced death of lung cancer cells by cleavage of the X-linked inhibitor of apoptosis protein (XIAP).
Maximizing binary interactome mapping with a minimal number of assays.
Cellular substrates and pro-apoptotic function of the human HtrA4 protease.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
A reference map of the human binary protein interactome.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
XAF1 prevents hyperproduction of type I interferon upon viral infection by targeting IRF7.
USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.
Understanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease.
Multimodal cell maps as a foundation for structural and functional genomics.
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors.
X-linked IAP is a direct inhibitor of cell-death proteases.
SMAC binds XIAP:Caspase-7
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
XIAP dissociates from ub-TLE
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.
X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axis.
ARTS mediates apoptosis and regeneration of the intestinal stem cell niche.
Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.