Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon
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MAP7D2 accumulates at the proximal part of the axon
"MAP7D2-N) accumulates at the proximal axon"
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MAP7D2 promotes kinesin-1-mediated cargo transport into axons
"Kinesin-1-Mediated Cargo Transport into the Axon"
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Depletion of MAP7D2 reduces axonal entry of organelle cargos
"Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon"
Deep research summary for MAP7D2 gene function
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MAP7D2's N-terminus binds microtubules; C-terminus interacts with kinesin-1
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MAP7D2 concentrates at the proximal axon/AIS in hippocampal neurons
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MAP7D2 recruits/activates kinesin-1 to promote cargo transport
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MAP7D2 directly binds microtubules via N-terminal half
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MAP7D2 stabilizes microtubules (loss reduces nocodazole resistance)
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MAP7D2 localizes to centrosomes and midbody during cytokinesis
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Binding affinity KD ~6x10^-7 M for microtubules
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MAP7 proteins act as microtubule-tethered kinesin-1 activators
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MAP7 family promotes kinesin-1 landing and increases processivity
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MAP7D2 significantly associated with age-related hearing loss
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MAP7D2 expressed in mouse and human inner ear tissues
Cyberian deep research on MAP7D2 function