ADCK5 is an atypical kinase implicated in cancer cell motility and in cellular senescence of airway epithelium. In lung cancer cells, ADCK5 phosphorylates the transcription factor SOX9 at serine 181, and phospho-SOX9 in turn upregulates the oncogene PTTG1, defining an ADCK5–SOX9–PTTG1 axis that drives invasion and migration PMID:32277958. In airway epithelial cells, ADCK5 overexpression elevates senescence markers (SA-β-gal, P21, P16), increases ROS and γH2AX, impairs mitochondrial membrane potential, and activates PI3K/AKT phosphorylation, placing ADCK5 upstream of the PI3K/AKT axis in senescence PMID:41222693. Beyond these gain-of-function and phenotypic studies, no direct in vitro reconstitution of ADCK5 kinase activity or substrate biochemistry has been characterized in the available corpus.
Recorded for reference. The AIGR evaluation found this grounding is coarse (collapses to general parents) and can contradict the narrative — do not import these GO ids directly; re-ground from the narrative + PMIDs.
| Year | Confidence | Finding | PMIDs | Journal |
|---|---|---|---|---|
| 2020 | Medium | ADCK5 promotes invasion and migration of lung cancer cells by phosphorylating transcription factor SOX9, with serine 181 identified as a required phosphorylation site; phospho-SOX9 then upregulates the oncogene PTTG1, defining an ADCK5-SOX9-PTTG1 signaling pathway. | PMID:32277958 | Experimental cell research |
| 2024 | Low | ADCK5 protein expression is upregulated in cancer cells following BET bromodomain inhibitor (JQ1) treatment, confirmed by immunoblotting, suggesting ADCK5 as a compensatory kinase target in BRD inhibitor resistance. | PMID:39241280 | Neoplasia (New York, N.Y.) |
| 2025 | Medium | ADCK5 overexpression in airway epithelial cells increases markers of cellular senescence (SA-β-gal-positive cells, P21, P16), elevates ROS and γH2AX, impairs mitochondrial membrane potential, and activates PI3K/AKT phosphorylation, placing ADCK5 upstream of the PI3K/AKT signaling axis in airway epithelial senescence. | PMID:41222693 | Naunyn-Schmiedeberg's archives of pharmacology |
| 2025 | Low | ADCK5 is identified as a highly expressed senescence-related gene in severe asthma airway cells; Leucokinin VIII acetate inhibits ADCK5 expression and reduces excessive cellular senescence in vitro, establishing ADCK5 as a driver of airway cell senescence. | PMID:40885090 | International immunopharmacology |
| 2024 | Low | A PPI network analysis identified strong interactions between ADCK5 and MFN1 (mitofusin-1) and between BNIP3 and NBR1 in the context of mitochondria-related gene networks, suggesting ADCK5 participates in mitochondrial protein interaction networks. | PMID:38783263 | BMC medical genomics |